ERIC Number: EJ903410
Record Type: Journal
Publication Date: 2010-Oct
Abstractor: As Provided
Reference Count: 0
Surrogate Endpoints in Suicide Research
Wortzel, Hal S.; Gutierrez, Peter M.; Homaifar, Beeta Y.; Breshears, Ryan E.; Harwood, Jeri E.
Suicide and Life-Threatening Behavior, v40 n5 p500-505 Oct 2010
Surrogate endpoints frequently substitute for rare outcomes in research. The ability to learn about completed suicides by investigating more readily available and proximate outcomes, such as suicide attempts, has obvious appeal. However, concerns with surrogates from the statistical science perspective exist, and mounting evidence from psychometric, neurochemical, genetic, and neuroimaging studies suggests that surrogates may be particularly problematic in suicide research. The need for greater phenotypic refinement of suicide-related behaviors, development of and adherence to a shared suicide nomenclature, and conservative interpretation of investigational results that are limited to the precise population and suicide-related behavior under examination are discussed.
Descriptors: Suicide, Psychometrics, Research, Genetics, Biochemistry, Behavior Patterns, Diagnostic Tests
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Publication Type: Journal Articles; Opinion Papers
Education Level: N/A
Authoring Institution: N/A