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ERIC Number: EJ899518
Record Type: Journal
Publication Date: 2010-Jun
Pages: 8
Abstractor: As Provided
Reference Count: 38
ISSN: ISSN-1940-5510
Historical Perspective on Mitochondrial Medicine
DiMauro, Salvatore; Garone, Caterina
Developmental Disabilities Research Reviews, v16 n2 p106-113 Jun 2010
In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis, uniparental inheritance, intergenomic signaling and its defects, and mitochondrial dynamics. We hope that this historical review also provides an update on mitochondrial medicine, although we fully realize that the speed of progress in this area makes any such endeavor akin to writing on water.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A