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ERIC Number: EJ898127
Record Type: Journal
Publication Date: 2010-Sep
Pages: 4
Abstractor: As Provided
Reference Count: 0
ISBN: N/A
ISSN: ISSN-1072-0502
Switching from Contextual to Tone Fear Conditioning and Vice Versa: The Key Role of the Glutamatergic Hippocampal-Lateral Septal Neurotransmission
Calandreau, Ludovic; Desgranges, Bertrand; Jaffard, Robert; Desmedt, Aline
Learning & Memory, v17 n9 p440-443 Sep 2010
The aim of the present experiment was to directly assess the role of the glutamatergic hippocampal-lateral septal (HPC-LS) neurotransmission in tone and contextual fear conditioning. We found that pretraining infusion of glutamatergic acid into the lateral septum promotes tone conditioning and concomitantly disrupts contextual conditioning. Infusion of glutamatergic antagonist, on the contrary, promotes contextual conditioning to the detriment of tone fear conditioning. These findings highlight the direct contribution of the glutamatergic HPC-LS neurotransmission to the adaptive selection among environmental stimuli of those that best predict the occurrence of the aversive event.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A