ERIC Number: EJ894137
Record Type: Journal
Publication Date: 2010-Sep
Abstractor: As Provided
Reference Count: 18
Digestive Enzyme Supplementation for Autism Spectrum Disorders: A Double-Blind Randomized Controlled Trial
Munasinghe, Sujeeva A.; Oliff, Carolyn; Finn, Judith; Wray, John A.
Journal of Autism and Developmental Disorders, v40 n9 p1131-1138 Sep 2010
To examine the effects of a digestive enzyme supplement in improving expressive language, behaviour and other symptoms in children with Autism Spectrum Disorder. Randomized, double-blind placebo-controlled trial using crossover design over 6 months for 43 children, aged 3-8 years. Outcome measurement tools included monthly Global Behaviour Rating Scales, Additional Rating Scales of other symptoms by parents and therapists, and monthly completion of the Rescorla Language Development Survey. Compared with placebo, treatment with enzyme was not associated with clinically significant improvement in behaviour, food variety, gastrointestinal symptoms, sleep quality, engagement with therapist, or the Language Development Survey Vocabulary or Sentence Complexity Scores. A small statistically significant improvement on enzyme therapy was seen for the food variety scores. No clinically significant effect improvement of autism symptoms with enzyme use was shown with this trial, however, possible effects on improvement in food variety warrants further detailed investigation.
Descriptors: Autism, Rating Scales, Biochemistry, Expressive Language, Language Acquisition, Pervasive Developmental Disorders, Metabolism, Child Behavior, Symptoms (Individual Disorders), Behavior Modification, Outcomes of Treatment, Eating Habits, Vocabulary Development
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Language Development Survey