ERIC Number: EJ891277
Record Type: Journal
Publication Date: 2010-Jul
Abstractor: As Provided
Reference Count: 0
Williams Syndrome and Memory: A Neuroanatomic and Cognitive Approach
Sampaio, Adriana; Sousa, Nuno; Fernandez, Montse; Vasconcelos, Cristiana; Shenton, Martha E.; Goncalves, Oscar F.
Journal of Autism and Developmental Disorders, v40 n7 p870-877 Jul 2010
Williams Syndrome (WS) is described as displaying a dissociation within memory systems. As the integrity of hippocampal formation (HF) is determinant for memory performance, we examined HF volumes and its association with memory measures in a group of WS and in a typically development group. A significantly reduced intracranial content was found in WS, despite no differences were observed for HF absolute volumes between groups. When volumes were normalized, left HF was increased in WS. Moreover, a lack of the normal right greater than left HF asymmetry was observed in WS. No positive correlations were found between volumetric and neurocognitive data in WS. In sum, a relative enlargement of HF and atypical patterns of asymmetry suggest abnormal brain development in WS.
Descriptors: Memory, Brain, Genetic Disorders, Cognitive Processes, Brain Hemisphere Functions, Comparative Analysis, Neurological Impairments, Neurological Organization
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A