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ERIC Number: EJ880302
Record Type: Journal
Publication Date: 2010-May
Pages: 7
Abstractor: As Provided
Reference Count: N/A
ISSN: ISSN-0162-3257
Pre-Eclampsia, Birth Weight, and Autism Spectrum Disorders
Mann, Joshua R.; McDermott, Suzanne; Bao, Haikun; Hardin, James; Gregg, Anthony
Journal of Autism and Developmental Disorders, v40 n5 p548-554 May 2010
Autism spectrum disorders (ASD) are primarily inherited, but perinatal or other environmental factors may also be important. In an analysis of 87,677 births from 1996 through 2002, insured by the South Carolina Medicaid program, birth weight was significantly inversely associated with the odds of ASD (OR = 0.78, p = 0.001 for each additional kilogram). Maternal pre-eclampsia/eclampsia was significantly associated with greater odds of ASD (OR = 1.85, p less than 0.0001 without controlling for birth weight; OR = 1.69, p = 0.0005, when controlling for birth weight). We conclude that reduced birth weight partially mediates the association between pre-eclampsia/eclampsia and ASD. Additional research is needed to investigate the potential mechanism(s) by which pre-eclampsia/eclampsia may influence ASD risk.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: South Carolina