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ERIC Number: EJ878719
Record Type: Journal
Publication Date: 2010-Mar
Pages: 21
Abstractor: As Provided
Reference Count: 44
ISSN: ISSN-0022-5002
A Choice Procedure to Assess the Aversive Effects of Drugs in Rodents
Podlesnik, Christopher A.; Jimenez-Gomez, Corina; Woods, James H.
Journal of the Experimental Analysis of Behavior, v93 n2 p203-223 Mar 2010
The goal of this series of experiments was to develop an operant choice procedure to examine rapidly the punishing effects of intravenous drugs in rats. First, the cardiovascular effects of experimenter-administered intravenous histamine, a known aversive drug, were assessed to determine a biologically active dose range. Next, rats responded on each of two levers with concurrently available fixed-ratio 1 schedules of food reinforcement. Intravenous histamine was delivered along with food when responses were made on one of the options, and the lever on which both food and histamine were contingent was switched on a regular basis. A dose of 1.0 mg/kg/inj of histamine was effective in moving responding to the alternate lever, whereas saline, 0.1, or 0.3 mg/kg/inj of histamine were not. Histamine injections produced reliable selection of the alternate lever when they were presented on the same lever for three consecutive sessions, but not when they were switched between levers on each session. In addition, histamine produced greater selection of the alternate lever when it was presented with shorter intertrial interval durations. These findings indicate that, with appropriate parameters, the aversive effects of histamine and perhaps other drugs can be rapidly established using a concurrent choice procedure. (Contains 9 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A