How can students learn to think for themselves, make good decisions, develop expertise, and become lifelong learners in a rapidly changing information environment? How can students learn, create, and find meaning from multiple sources of information? These are fundamental questions facing educators in designing schools for 21st-century learners. Guided inquiry is a practical way of implementing an inquiry approach that addresses these 21st-century learning needs for students. Guided inquiry is based on extensive studies of the Information Search Process (ISP) in assigned research projects. Because the implementation of learning through inquiry is complex and multi-faceted, it takes a team to teach and assess. A three-member core team to plan and supervise the inquiry is recommended with an extended team of other experts joining in when they are needed. A team approach takes full advantage of the expertise of the school and community. This article presents examples that illustrate the use of core and extended teams in primary, middle, and high school. After each example, there is a closer look at how the team works together to support the learning and assessment needs through the unit. (Contains 5 figures.)