ERIC Number: EJ872696
Record Type: Journal
Publication Date: 2010-Feb
Abstractor: As Provided
Reference Count: 0
Prefrontal Control of Familiarity and Recollection in Working Memory
Feredoes, Eva; Postle, Bradley R.
Journal of Cognitive Neuroscience, v22 n2 p323-330 Feb 2010
Left inferior frontal gyrus (IFG) is a critical neural substrate for the resolution of proactive interference (PI) in working memory. We hypothesized that left IFG achieves this by controlling the influence of familiarity- versus recollection-based information about memory probes. Consistent with this idea, we observed evidence for an "early" (200 msec)-peaking signal corresponding to memory probe familiarity and a "late" (500 msec)-resolving signal corresponding to full accrual of trial-related contextual ("recollection-based") information. Next, we applied brief trains of repetitive transcranial magnetic stimulation (rTMS) time locked to these mnemonic signals, to left IFG and to a control region. Only early rTMS of left IFG produced a modulation of the false alarm rate for high-PI probes. Additionally, the magnitude of this effect was predicted by individual differences in susceptibility to PI. These results suggest that left IFG-based control may bias the influence of familiarity- and recollection-based signals on recognition decisions.
Descriptors: Familiarity, Short Term Memory, Brain, Evaluation Methods, Science Education, Recognition (Psychology), Decision Making
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A