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ERIC Number: EJ871451
Record Type: Journal
Publication Date: 2010-Jan
Pages: 41
Abstractor: As Provided
Reference Count: 464
ISSN: ISSN-0033-295X
Allostasis and the Human Brain: Integrating Models of Stress from the Social and Life Sciences
Ganzel, Barbara L.; Morris, Pamela A.; Wethington, Elaine
Psychological Review, v117 n1 p134-174 Jan 2010
We draw on the theory of allostasis to develop an integrative model of the current stress process that highlights the brain as a dynamically adapting interface between the changing environment and the biological self. We review evidence that the core emotional regions of the brain constitute the primary mediator of the well-established association between stress and health, as well as the neural focus of wear and tear due to ongoing adaptation. This mediation, in turn, allows us to model the interplay over time between context, current stressor exposure, internal regulation of bodily processes, and health outcomes. We illustrate how this approach facilitates the integration of current findings in human neuroscience and genetics with key constructs from stress models from the social and life sciences, with implications for future research and the design of interventions targeting individuals at risk. (Contains 6 figures and 7 footnotes.)
American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002-4242. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A