This paper examined the everyday challenges, stressors and coping strategies of orphans affected by HIV/AIDS in Nyanza, Kenya. A thematic analysis of six focus group discussions with orphans was guided by Stress and Coping Theoretical Framework. The orphans reported intense stress at the time of their parents' death with their immediate concern being who would care for them. Most orphans were separated from their siblings, and this separation only compounded the Stressors and difficulties encountered by orphans. Orphans reported having problems with schooling and being treated differently as compared with the children of their caregivers. Orphans adopted various emotion-focused and problem-focused coping strategies, which were reinforced by financial and social support provided by their caregivers and community-based organizations. (Contains 1 table.)