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ERIC Number: EJ858295
Record Type: Journal
Publication Date: 2009-Nov
Pages: 10
Abstractor: As Provided
Reference Count: 0
ISSN: ISSN-0162-3257
Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder
Gadow, Kenneth D.; Roohi, Jasmin; Devincent, Carla J.; Kirsch, Sarah; Hatchwell, Eli
Journal of Autism and Developmental Disorders, v39 n11 p1542-1551 Nov 2009
The aim of the study is to examine rs4680 ("COMT") and rs6265 ("BDNF") as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both "COMT" (p = 0.06) and "BDNF" (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia ([eta]p [superscript 2] = 0.06). Analyses also indicated associations of "BDNF" genotype with parent-rated ADHD (p = 0.01, [eta]p [superscript 2] = 0.10) and teacher-rated tics (p = 0.04; [eta]p [superscript 2] = 0.07). There was also evidence of a possible interaction (p = 0.02, [eta]p [superscript 2] = 0.09) of "BDNF" genotype with "DAT1" 3' VNTR with tic severity. "BDNF" and "COMT" may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A