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ERIC Number: EJ855116
Record Type: Journal
Publication Date: 2009-Oct
Pages: 6
Abstractor: As Provided
Reference Count: 0
ISBN: N/A
ISSN: ISSN-0162-3257
Brief Report: Parental Age and the Sex Ratio in Autism
Anello, Alene; Reichenberg, Abraham; Luo, Xiaodong; Schmeidler, James; Hollander, Eric; Smith, Christopher J.; Puleo, Connor M.; Kryzak, Lauren A.; Silverman, Jeremy M.
Journal of Autism and Developmental Disorders, v39 n10 p1487-1492 Oct 2009
The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (less than 30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A