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ERIC Number: EJ853497
Record Type: Journal
Publication Date: 2009-Sep
Pages: 3
Abstractor: As Provided
Reference Count: 11
ISSN: ISSN-0021-9584
A Green Multicomponent Reaction for the Organic Chemistry Laboratory: The Aqueous Passerini Reaction
Hooper, Matthew M.; DeBoef, Brenton
Journal of Chemical Education, v86 n9 p1077-1079 Sep 2009
Water is the ideal green solvent for organic reactions. However, most organic molecules are insoluble in it. Herein, we report a laboratory module that takes advantage of this property. The Passerini reaction, a three-component coupling involving an isocyanide, aldehyde, and carboxylic acid, typically requires [similar to] 24 h reaction times in organic solvents, but produces a quantitative conversion and yield in less than 30 min when performed in water. This rate enhancement allows the Passerini reaction to be easily adapted for use in a second-year organic laboratory course. Additionally, the incorporation of this laboratory module facilitates discussions of both green chemistry and combinatorial chemistry in the curriculum. (Contains 2 schemes and 2 notes.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A