ERIC Number: EJ850219
Record Type: Journal
Publication Date: 2009-Jan
Abstractor: As Provided
Reference Count: 0
Recurrence Risk after a First Remote Symptomatic Unprovoked Seizure in Childhood: A Prospective Study
Ramos-Lizana, J.; Aguirre-Rodriguez, J.; Aguilera-Lopez, P.; Cassinello-Garcia, E.
Developmental Medicine & Child Neurology, v51 n1 p68-73 Jan 2009
The aim of this study was to assess recurrence risk after a first remote symptomatic unprovoked seizure in childhood. All consecutive patients younger than 14 years with a first remote symptomatic unprovoked seizure who were seen at our hospital between 1994 and 2006 were included in the study and prospectively followed. Only two patients received antiepileptic treatment. Sixty-three children were included, with 35 males and 28 females. Mean age at first seizure was 4 years (SD 3y 5mo). Kaplan-Meier estimate of recurrence risk was 59% (95% confidence interval [CI] 47-71), 76% (95% CI 65-87), 85% (95% CI 76-94), and 87% (95% CI 78-96) at 6, 12, 18, and 24 months respectively. A total of 55 children out of 63 were affected by a static encephalopathy of pre- or perinatal origin. In this subgroup, recurrence risk at 12 and 24 months was 79% (95% CI 68-90) and 89% (95% CI 80-98). Univariable analysis using the Cox proportional hazards model showed that presence of global developmental delay/intellectual disability and Todd's paresis were associated with a significant increase in recurrence risk. In multivariable analysis, only Todd's paresis was significantly associated. Recurrence risk after a first remote symptomatic unprovoked seizure in childhood is much higher than what some previous studies suggests.
Descriptors: Seizures, Risk, Children, Incidence, Developmental Delays, Mental Retardation, Physical Disabilities, Age Differences
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A