ERIC Number: EJ849705
Record Type: Journal
Publication Date: 2009-May
Abstractor: As Provided
Reference Count: 0
Exogenous Melatonin for Sleep Problems in Individuals with Intellectual Disability: A Meta-Analysis
Braam, Wiebe; Smits, Marcel G.; Didden, Robert; Korzilius, Hubert; van Geijlswijk, Ingeborg M.; Curfs, Leopold M. G.
Developmental Medicine & Child Neurology, v51 n5 p340-349 May 2009
Recent meta-analyses on melatonin has raised doubts as to whether melatonin is effective in treating sleep problems in people without intellectual disabilities. This is in contrast to results of several trials on melatonin in treating sleep problems in individuals with intellectual disabilities. To investigate the efficacy of melatonin in treating sleep problems in individuals with intellectual disabilities, we performed a meta-analysis of placebo-controlled randomized trials of melatonin in individuals with intellectual disabilities and sleep problems. Data were selected from articles published on PubMed, Medline, and Embase between January 1990 and July 2008. We examined the influence of melatonin on sleep latency, total sleep time, and number of wakes per night. Quality of trials was assessed using the Downs and Black checklist. Nine studies (including a total of 183 individuals with intellectual disabilities) showed that melatonin treatment decreased sleep latency by a mean of 34 minutes (p less than 0.001), increased total sleep time by a mean of 50 minutes (p less than 0.001), and significantly decreased the number of wakes per night (p less than 0.05). Melatonin decreases sleep latency and number of wakes per night, and increases total sleep time in individuals with intellectual disabilities.
Descriptors: Mental Retardation, Sleep, Meta Analysis, Drug Therapy, Outcomes of Treatment, Literature Reviews, Comparative Analysis
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
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