ERIC Number: EJ846300
Record Type: Journal
Publication Date: 2005
Abstractor: As Provided
Reference Count: 0
Mechanisms of Aminoglycoside-Induced Hair Cell Death
Mangiardi, Dominic A.; Cotanche, Douglas A.
Volta Review, v105 n3 p357-370 Win 2005
Aminoglycoside antibiotics are commonly used because of their ability to treat bacterial infections, yet they also are a major cause of deafness. Aminoglycosides selectively damage the cochlea's sensory hair cells, the receptors that respond to the fluid movement in the cochlea to produce neural signals that are relayed to the brain. Sensory hair cell death in the inner ear can lead to permanent hearing loss and balance impairment. A primary mechanism of aminoglycoside-induced hair cell death is the induction of apoptosis. Apoptosis is an evolutionarily conserved form of cell death that provides organisms with a method to remove unwanted or damaged cells without injuring neighboring cells. The role of apoptosis in aminoglycoside-induced hair cell death is discussed in this article, as are the implications for developing methods to protect sensory hair cells.
Descriptors: Hearing Impairments, Cytology, Drug Therapy, Symptoms (Individual Disorders), Deafness, Molecular Structure
Alexander Graham Bell Association for the Deaf and Hard of Hearing. 3417 Volta Place NW, Washington, DC 20007. Tel: 202-337-5220; Fax: 202-337-8314; e-mail: firstname.lastname@example.org; Web site: http://www.agbell.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A