ERIC Number: EJ846286
Record Type: Journal
Publication Date: 2005
Abstractor: As Provided
Reference Count: 0
Vesibulotoxicity and Management of Vestibular Disorders
Carey, John P.
Volta Review, v105 n3 p251-276 Win 2005
The toxicity of certain aminoglycoside antibiotics for vestibular hair cells has been used to special advantage in the treatment of Meniere's disease. Intratympanic (middle ear) injections of these drugs are being increasingly used to control vertigo in this disorder when it has not responded to medical therapy. The mechanisms by which these drugs enter and affect the hair cells and the subsequent effects on the vestibular nerves and reflexes will be reviewed. The risk of hearing loss from these treatments compares favorably to the risk of hearing loss from the natural history of the disease or from other surgical treatments. The use of intratympanic gentamicin in Meniere's disease and other disorders will be discussed. Finally, potential therapies to prevent ototoxic damage will also be reviewed.
Descriptors: Drug Therapy, Diseases, Symptoms (Individual Disorders), Pharmacology, Hearing Impairments, Cytology
Alexander Graham Bell Association for the Deaf and Hard of Hearing. 3417 Volta Place NW, Washington, DC 20007. Tel: 202-337-5220; Fax: 202-337-8314; e-mail: firstname.lastname@example.org; Web site: http://www.agbell.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A