ERIC Number: EJ843522
Record Type: Journal
Publication Date: 2009-Jul
Abstractor: As Provided
Reference Count: 64
Performance on the Modified Card Sorting Test and Its Relation to Psychopathology in Adolescents and Young Adults with 22Q11.2 Deletion Syndrome
Rockers, K.; Ousley, O.; Sutton, T.; Schoenberg, E.; Coleman, K.; Walker, E.; Cubells, J. F.
Journal of Intellectual Disability Research, v53 n7 p665-676 Jul 2009
Background: Approximately one-third of individuals with 22q11.2 deletion syndrome (22q11DS), a common genetic disorder highly associated with intellectual disabilities, may develop schizophrenia, likely preceded by a mild to moderate cognitive decline. Methods: We examined adolescents and young adults with 22q11DS for the presence of executive function deficits using a modified version of the Wisconsin Card Sorting Test (MCST) and assessed whether specific performances were associated with concurrent schizophrenia-prodrome symptoms. We also examined possible relationships between MCST performance and broader indices of psychopathology, including self-reported internalising and externalising behavioural symptoms. Results: Participants with 22q11DS scored significantly below age-matched controls on seven out of nine MCST measures, and poorer MCST performance was associated with increased positive prodromal and internalising behavioural symptoms. Conclusions: The schizophrenia-prodrome in 22q11DS involves executive dysfunction, and longitudinal investigation is necessary to examine if specific executive function impairments precedes or co-occurs with the emergence of behavioural psychopathology.
Descriptors: Genetic Disorders, Mental Retardation, Schizophrenia, Psychopathology, Young Adults, Adolescents, Cognitive Processes, Symptoms (Individual Disorders), At Risk Persons, Neurological Impairments, Behavior Problems
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A