ERIC Number: EJ839930
Record Type: Journal
Publication Date: 2009-Jun
Abstractor: As Provided
Reference Count: N/A
The Role of Gene DCDC2 in German Dyslexics
Wilcke, A.; Weissfuss, J.; Kirsten, H.; Wolfram, G.; Boltze, J.; Ahnert, P.
Annals of Dyslexia, v59 n1 p1-11 Jun 2009
Dyslexia is a complex reading and writing disorder with a strong genetic component. In a German case-control cohort, we studied the influence of the suspected dyslexia-associated gene DCDC2. For the first time in a German cohort, we describe association of a 2445 basepair deletion, first identified in an American study. Evidence of association for three DCDC2 single nucleotide polymorphisms (rs807724, rs793862, rs807701), previously identified in German or American cohorts, was replicated. A haplotype of these polymorphisms showed evidence for association as well. Thus, our data further corroborate association of DCDC2 with dyslexia. Analysis of functional subgroups suggests association of investigated DCDC2 variants mainly with nondysphonetic, nonsevere, but probably dyseidetic (surface) dyslexia. Based on the presumed function of DCDC2, our findings point to a role of impaired neuronal migration in the etiology of the disease.
Descriptors: Dyslexia, Genetics, Etiology, Genetic Disorders, Foreign Countries, Influences, Correlation, Symptoms (Individual Disorders), Neurological Impairments
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Germany