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ERIC Number: EJ838107
Record Type: Journal
Publication Date: 2009-Apr
Pages: 6
Abstractor: As Provided
Reference Count: 56
ISSN: ISSN-1072-0502
Amyloid Beta Mediates Memory Formation
Garcia-Osta, Ana; Alberini, Cristina M.
Learning & Memory, v16 n4 p267-272 Apr 2009
The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid [beta] (1-42) peptide (A[beta][1-42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated, endogenous A[beta] in normal hippocampi mediates learning and memory formation. Furthermore, hippocampal injection of picomolar concentrations of exogenous A[beta](1-42) enhances memory consolidation. Correlative data suggest that A[beta] peptides may exert their function via nicotinic acetylcoline receptors. Hence, A[beta] peptides, including A[beta](1-42), play an important physiological role in hippocampal memory formation. (Contains 3 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A