Sexual minority youth commonly face struggles in adapting to unwelcoming or threatening school climates. In one Midwestern city, several schools receive services from Out For Equity (OFE), a flagship program supporting lesbian, gay, bisexual, transgender, questioning, and allied (LGBTQA) youth. Participating schools indicated consistent improvement in overall campus climate, according to a series of surveys spanning four years. An initiative implemented in three schools also resulted in significant improvement in student perceptions of safety, comfort, and teacher intervention, suggesting the need for sustained system-wide interventions that make effective use of available resources. Emerging themes in results are discussed and directions for future research are provided. (Contains 3 figures.)