In an era of global competition and a technology-based economy, it is increasingly important that college students graduate with a solid foundation of knowledge and understanding of science and mathematics. They must be able to use their scientific knowledge on their jobs and in their role as citizens of a society where complex policy and resource questions, for example, on cloning, stem cell research, greenhouse gases, and sustainability, increasingly have dimensions related to science and technology. Two clear conclusions have emerged from the chapters in this volume. First, in order to create a climate that supports undergraduate teaching and learning in STEM (science, technology, engineering, and mathematics) fields, the task must be addressed at multiple levels by all of the stakeholders concerned about the quality of STEM undergraduate education. Second, these stakeholders need to coordinate their efforts to maximize their impact. Building a climate that truly supports STEM undergraduate education is much more likely to occur if the key stakeholders coordinate their efforts, communicate, share information and resources, and speak with a unified voice about the importance of reforming undergraduate education in STEM. In other words, this challenge needs to be addressed systemically. In this chapter, the author describes the important elements of what should be a systematic, coordinated strategy to strengthen STEM undergraduate teaching and learning by engaging stakeholders from the individual classroom and laboratory to the national policy level.