ERIC Number: EJ832502
Record Type: Journal
Publication Date: 2009-Apr
Abstractor: As Provided
Reference Count: 12
A Two-Step Synthesis of Virstatin, a Virulence Inhibitor of "Vibrio cholerae"
McDonald, Chriss E.
Journal of Chemical Education, v86 n4 p482-483 Apr 2009
Virstatin, an "N"-butanoic acid substituted naphthalimide, inhibits the ability of "Vibrio cholerae" to cause disease. A three-week experiment involving synthesis, purification, and spectral characterization of this compound is described. This experiment is appropriate for organic chemistry. It has been performed with three lab sections of about fifteen students each and can be executed in three laboratory periods each lasting three hours. (Contains 1 scheme.)
Descriptors: Organic Chemistry, Laboratory Experiments, Microbiology, Communicable Diseases, College Science, Active Learning, Inquiry, Hazardous Materials, Science Instruction, Hands on Science, Spectroscopy, Chemistry, Medicine, Undergraduate Study
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: email@example.com; Web site: http://www.jce.divched.org
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Authoring Institution: N/A