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ERIC Number: EJ832501
Record Type: Journal
Publication Date: 2009-Apr
Pages: 3
Abstractor: As Provided
Reference Count: 7
ISSN: ISSN-0021-9584
Analysis of Dextromethorphan in Cough Drops and Syrups: A Medicinal Chemistry Laboratory
Hamilton, Todd M.; Wiseman, Frank L., Jr.
Journal of Chemical Education, v86 n4 p479-481 Apr 2009
Fluorescence spectroscopy is used to determine the quantity of dextromethorphan hydrobromide (DM) in over-the-counter (OTC) cough drops and syrups. This experiment is appropriate for an undergraduate medicinal chemistry laboratory course when studying OTC medicines and active ingredients. Students prepare the cough drops and syrups for analysis, compare their results with analysis of a DM standard solution and explore interference from other ingredients (food coloring, corn syrup, and methyl cellulose). Students also perform a standard addition analysis to obtain a quantitative result for the quantity of DM in a cough medicine. This experiment can be a straightforward laboratory exercise to be completed in one laboratory period or an open-ended investigation spanning two or more laboratory periods. This exercise gives students experience in chemical analysis of an OTC medicine and could be extended to other medications or food products. (Contains 4 figures, 3 tables, and 1 note.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A