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ERIC Number: EJ832488
Record Type: Journal
Publication Date: 2009-Mar
Pages: 5
Abstractor: As Provided
Reference Count: 4
ISSN: ISSN-0021-9584
An "Aufbau" Approach to Understanding How the King-Altman Method of Deriving Rate Equations for Enzyme-Catalyzed Reactions Works
Sims, Paul A.
Journal of Chemical Education, v86 n3 p385-389 Mar 2009
The King-Altman method of deriving rate equations for enzymatic reactions is applied to the derivation of the Michaelis-Menten equation, along with an explanation for how (or why) the King-Altman method works in this case. The slightly more complicated cases of competitive inhibition and a two-substrate enzyme-catalyzed reaction are then treated in the same manner. It is the intent of the author that through this process of seeing how the King-Altman method works in progressively more complicated cases, a student is in a better position to appreciate the generality of the method and, perhaps, the general proof of the method. (Contains 3 figures.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A