ERIC Number: EJ831603
Record Type: Journal
Publication Date: 2009-Apr
Abstractor: As Provided
Reference Count: 0
Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials during Processing of Illusory Figures in Autism
Sokhadze, Estate M.; El-Baz, Ayman; Baruth, Joshua; Mathai, Grace; Sears, Lonnie; Casanova, Manuel F.
Journal of Autism and Developmental Disorders, v39 n4 p619-634 Apr 2009
Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism.
Descriptors: Stimulation, Autism, Patients, Cognitive Processes, Information Processing, Outcomes of Treatment, Intervention, Inhibition
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A