While most school districts utilize a drug abuse resistance curriculum, as science teachers, it is our responsibility to understand the science behind drug addiction in order to most effectively educate our students against drug abuse. In the last two decades, increases in scientific technology have permitted significant discoveries surrounding the neurobiology, genetic components, and treatment of drug addition. This article addresses the latest scientific knowledge about drug addition and treatment with information that can be used in the middle school setting, focusing on cocaine addiction to illustrate the points discussed. (Contains 2 online resources.)