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ERIC Number: EJ827484
Record Type: Journal
Publication Date: 2009-Feb
Pages: 7
Abstractor: As Provided
Reference Count: 0
ISSN: ISSN-1072-0502
Boundary Conditions for the Maintenance of Memory by PKM[zeta] in Neocortex
Shema, Reul; Hazvi, Shoshi; Sacktor, Todd C.; Dudai, Yadin
Learning & Memory, v16 n2 p122-128 Feb 2009
We report here that ZIP, a selective inhibitor of the atypical protein kinase C isoform PKM[zeta], abolishes very long-term conditioned taste aversion (CTA) associations in the insular cortex of the behaving rat, at least 3 mo after encoding. The effect of ZIP is not replicated by a general serine/threonine protein kinase inhibitor that is relatively ineffective toward PKM[zeta], is independent of the intensity of training and the perceptual quality of the taste saccharin (conditioned stimulus, CS), and does not affect the ability of the insular cortex to re-encode the same specific CTA association again. The memory trace is, however, insensitive to ZIP during or immediately after training. This implies that the experience-dependent cellular plasticity mechanism targeted by ZIP is established following a brief time window after encoding, consistent with the standard period of cellular consolidation, but then, once established, does not consolidate further to gain immunity to the amnesic agent. Hence, we conclude that PKM[zeta] is not involved in short-term CTA memory, but is a critical component of the cortical machinery that stores long- and very long-term CTA memories.
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Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A