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ERIC Number: EJ827394
Record Type: Journal
Publication Date: 2008-Jun
Pages: 2
Abstractor: As Provided
Reference Count: 12
ISSN: ISSN-0021-9584
Polymer-Supported Reagents and [to the first power]H-[to the nineteenth power]F NMR Couplings: The Synthesis of 2-Fluoroacetophenone
Pohl, Nicola; Schwarz, Kimberly
Journal of Chemical Education, v85 n6 p834-835 Jun 2008
We describe an experiment for the undergraduate organic laboratory curriculum in which 2-bromoacetophenone is converted to 2-fluoroacetophenone using a solid-phase nucleophilic fluorine source. The experiment introduces students to the utility of solid-phase reagents in organic synthesis, to NMR-active nuclei other than [to the first power]H without the requirement of a special NMR probe, and to the unique uses of fluorine in molecular design. (Contains 1 scheme.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A