College students with chronic illness find it difficult to succeed in traditional degree programs due to disruptions caused by relapses and unpredictable waxing and waning symptoms. College disability offices are often unable to help, both because their standard supports are not appropriate and because students with chronic illness frequently do not identify themselves as having a disability. This Practice Brief discusses the need for specific programs tailored to the culture of postsecondary students with chronic illness. The Chronic Illness Initiative at DePaul University is presented as a model for such programs. (Contains 2 endnotes.)