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ERIC Number: EJ825652
Record Type: Journal
Publication Date: 2009-Feb
Pages: 6
Abstractor: As Provided
Reference Count: 0
ISBN: N/A
ISSN: ISSN-0278-2626
Anomalous Brain Dominance and the Immune System: Do Left-Handers Have Specific Immunological Patterns?
Lengen, Charis; Regard, Marianne; Joller, Helen; Landis, Theodor; Lalive, Patrice
Brain and Cognition, v69 n1 p188-193 Feb 2009
Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) suggested a correlation between brain laterality and immune disorders. To test whether this hypothesis holds true not only for the frequency of immune diseases and circulating autoantibodies, but extends also to cellular immunity, we examined the association between handedness and markers of cellular immunity. Twenty-seven left-handed and 37 right-handed subjects were serologically screened for cellular parameters and 22 left-handed subjects were typed for human leukocyte antigen (HLA). When compared to the right-handers, the left-handed group showed a significant decrease in the inflammatory cell types CD3[superscript +] T cells (total T cells), CD4[superscript +] T cells (T-helper cells), and HLA-Dr (MHC-II, antigen-presenting cells) as well as in the CD19[superscript +] cells (B cells) and CD16/CD57[superscript +] cells (natural killer cells). We assume a relationship exists between cerebral hemispheric specialisation and the immune system not only for humoral but also for cellular immunity, and we discuss the role of the major histocompatibility complex in neurological and immunological development. (Contains 2 tables and 2 figures.)
Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A