ERIC Number: EJ825247
Record Type: Journal
Publication Date: 2009-Feb
Abstractor: As Provided
Reference Count: 0
GABA[subscript A] Receptor Downregulation in Brains of Subjects with Autism
Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Thuras, Paul D.
Journal of Autism and Developmental Disorders, v39 n2 p223-230 Feb 2009
Gamma-aminobutyric acid A (GABA[subscript A]) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABA[subscript A] receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann's Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABA[subscript A] receptor subunit expression in the three brain areas. Our results demonstrate that GABA[subscript A] receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism.
Descriptors: Autism, Pathology, Brain, Cognitive Processes, Neurological Organization, Brain Hemisphere Functions, Seizures, Neurological Impairments
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A