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ERIC Number: EJ823773
Record Type: Journal
Publication Date: 2008-Dec
Pages: 2
Abstractor: As Provided
Reference Count: 11
ISSN: ISSN-0021-9584
Salicylate Detection by Complexation with Iron(III) and Optical Absorbance Spectroscopy: An Undergraduate Quantitative Analysis Experiment
Mitchell-Koch, Jeremy T.; Reid, Kendra R.; Meyerhoff, Mark E.
Journal of Chemical Education, v85 n12 p1658-1659 Dec 2008
An experiment for the undergraduate quantitative analysis laboratory involving applications of visible spectrophotometry is described. Salicylate, a component found in several medications, as well as the active by-product of aspirin decomposition, is quantified. The addition of excess iron(III) to a solution of salicylate generates a deeply colored solution whose absorbance can be easily measured. The salicylate content in over-the-counter acne medications and an unknown is determined after construction of a linear calibration curve. Further, the nature of the iron-salicylate interaction can be investigated by using the method of continuous variation (Job's method) to determine the predominant stoichiometry of the complex. This experiment is easily adapted to a wide variety of available instrumentation and has been successfully tested at both the University of Michigan and Emporia State University. It is possible to complete the entire experiment in a single three-hour laboratory period, but splitting it into two sessions allows students to analyze their data as it is collected. (Contains 2 figures.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A