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ERIC Number: EJ823759
Record Type: Journal
Publication Date: 2008-Oct
Pages: 2
Abstractor: As Provided
Reference Count: 7
ISSN: ISSN-0021-9584
Synthesis of the Commercial Antidepressant Moclobemide
More, Jesse D.
Journal of Chemical Education, v85 n10 p1424-1425 Oct 2008
An experiment for the undergraduate organic chemistry laboratory is described in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix. This one-step synthesis starts from commercially available material and produces moclobemide in high yield. The product is initially isolated as its hydrochloride salt via precipitation. After recrystallization and treatment with base moclobemide is isolated in pure form. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy. (Contains 2 figures and 2 schemes.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A