ERIC Number: EJ822607
Record Type: Journal
Publication Date: 2009-Jan
Abstractor: As Provided
Reference Count: 0
Association of a Monoamine Oxidase-A Gene Promoter Polymorphism with ADHD and Anxiety in Boys with Autism Spectrum Disorder
Roohi, Jasmin; DeVincent, Carla J.; Hatchwell, Eli; Gadow, Kenneth D.
Journal of Autism and Developmental Disorders, v39 n1 p67-74 Jan 2009
The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p less than 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.
Descriptors: Autism, Rating Scales, Anxiety, Males, Attention Deficit Hyperactivity Disorder, Pervasive Developmental Disorders, Children, Adolescents, Comparative Analysis, Severity (of Disability), Symptoms (Individual Disorders), Genetic Disorders
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A