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ERIC Number: EJ820913
Record Type: Journal
Publication Date: 2007-Dec
Pages: 7
Abstractor: As Provided
Reference Count: 57
ISBN: N/A
ISSN: ISSN-0021-9584
Unequal Activities of Enantiomers via Biological Receptors: Examples of Chiral Drug, Pesticide, and Fragrance Molecules
Mannschreck, Albrecht; Kiesswetter, Roland; von Angerer, Erwin
Journal of Chemical Education, v84 n12 p2012-2018 Dec 2007
A molecule coming from outside an organism can form a ligand-receptor complex. Upon its formation, a message is transmitted, for example, to certain cells. In this way, two enantiomers can emit messages that differ, either quantitatively or qualitatively. In the present article, these facts are taken as a common basis for the actions of chiral drug, pesticide, and fragrance molecules. For each of these groups, a few examples of current interest were selected. At present, the demand for single enantiomers in medicine and agriculture is economically highly significant. We propose a two-hour lecture, emphasizing the similarity between the different types of receptor-mediated actions of enantiomers, thus connecting some seemingly unrelated subjects in the university curricula. The lecture is intended for medicinal chemistry students; in addition, it should be suitable for the third-year chemistry students who are interested in the applications presented here. (Contains 5 tables, 5 figures, and 1 scheme.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: Students; Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A