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ERIC Number: EJ820751
Record Type: Journal
Publication Date: 2007-Mar
Pages: 2
Abstractor: As Provided
Reference Count: 14
ISBN: N/A
ISSN: ISSN-0021-9584
Using a Premade Grignard Reagent to Synthesize Tertiary Alcohols in a Convenient Investigative Organic Laboratory Experiment
Berg, Michael A. G.; Pointer, Roy D.
Journal of Chemical Education, v84 n3 p483-484 Mar 2007
A commercially available Grignard reagent (3.0 M solution of phenyl magnesium bromide in ether) was used in a convenient Grignard synthesis in a second-year organic chemistry laboratory without any of the typical failures associated with the Grignard reaction. The reaction setup used oven-dried glassware and no extraordinary measures were taken to keep the reaction under inert atmosphere. The Grignard reagent was dispensed into students' reaction vessels by the instructor. The students then slowly added a solution of a ketone. The yields of the resulting tertiary alcohols were good to excellent. Additional activities included determination of recrystallization solvent and characterization of their purified products using TLC, mp, IR, and NMR spectroscopy. This lab was used as the student's first exposure to a synthesis-type experiment and occurred early in the second-semester organic course corresponding to the lecture material concerning Grignard reactions. (Contains 1 table.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: Students; Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A