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ERIC Number: EJ820309
Record Type: Journal
Publication Date: 2006-Nov
Pages: 3
Abstractor: As Provided
Reference Count: 14
ISSN: ISSN-0021-9584
Microwave-Mediated Synthesis of Lophine: Developing a Mechanism to Explain a Product
Crouch, R. David; Howard, Jessica L.; Zile, Jennifer L.; Barker, Kathryn H.
Journal of Chemical Education, v83 n11 p1658-1660 Nov 2006
The microwave-mediated preparation of lophine (2,4,5-triphenylimidazole) is described. This experiment allows for an introduction to the emerging technology of microwave-assisted organic synthesis while providing an opportunity for students to employ the principles of carbonyl chemistry in devising a mechanism to explain the formation of the product. When combined with previously published methods for heterocycle synthesis, this experiment offers an example of the advantages of microwave-assisted synthesis. (Contains 2 schemes.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A