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ERIC Number: EJ820307
Record Type: Journal
Publication Date: 2006-Nov
Pages: 4
Abstractor: As Provided
Reference Count: 27
ISSN: ISSN-0021-9584
Creatine Synthesis: An Undergraduate Organic Chemistry Laboratory Experiment
Smith, Andri L.; Tan, Paula
Journal of Chemical Education, v83 n11 p1654-1657 Nov 2006
Students in introductory chemistry classes typically appreciate seeing the connection between course content and the "real world". For this reason, we have developed a synthesis of creatine monohydrate--a popular supplement used in sports requiring short bursts of energy--for introductory organic chemistry laboratory courses. Creatine monohydrate is easily synthesized from N-methylglycine (sarcosine) and cyanamide in the presence of salt and base. The crude product is purified by recrystallization and analyzed by thin-layer chromatography, melting point, and nuclear magnetic resonance spectroscopy. This synthesis illustrates the electrophilic nature of nitriles, as well as the nucleophilic nature of amines. (Contains 3 schemes and 2 notes.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A