ERIC Number: EJ818778
Record Type: Journal
Publication Date: 2008-Nov
Abstractor: As Provided
Reference Count: 0
Progesterone Regulation of Synaptic Transmission and Plasticity in Rodent Hippocampus
Foy, Michael R.; Akopian, Garnik; Thompson, Richard F.
Learning & Memory, v15 n11 p820-822 Nov 2008
Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with long-term potentiation (LTP) and long-term depression (LTD) were studied using in vitro hippocampal slices. Extracellular studies show that the highest concentration of P4 tested (10[superscript -6] M) decreased the baseline synaptic transmission and magnitude of LTP, but did not affect LTD. Intracellular studies suggest the P4 effect to be mediated, at least in part, by GABA[subscript A] activity. These results establish a general effect of P4 on synaptic transmission, multiple forms of synaptic plasticity, and a possible mechanism of P4 action in hippocampus.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A