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ERIC Number: EJ818776
Record Type: Journal
Publication Date: 2008-Nov
Pages: 5
Abstractor: As Provided
Reference Count: 0
ISSN: ISSN-1072-0502
PKM[zeta] Inactivation Induces Spatial Familiarity
Moncada, Diego; Viola, Haydee
Learning & Memory, v15 n11 p810-814 Nov 2008
Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKM[zeta] levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKM[zeta], while inactivation of hippocampal PKM[zeta] by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKM[zeta] is involved in setting a given context as a familiar place.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A