ERIC Number: EJ818331
Record Type: Journal
Publication Date: 2008-Nov
Abstractor: As Provided
Reference Count: N/A
Brief Report: No Association between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin
Schirmbeck, Frederike; Georgi, Alexander; Strohmaier, Jana; Schmael, Christine; Boesshenz, Katja V.; Muhleisen, Thomas W.; Herms, Stefan; Hoffmann, Per; Jamra, Rami Abou; Schumacher, Johannes; Maier, Wolfgang; Propping, Peter; Nothen, Markus M.; Cichon, Sven; Rietschel, Marcella; Schulze, Thomas G.
Journal of Autism and Developmental Disorders, v38 n10 p1977-1981 Nov 2008
Whereas "Dysbindin" is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. ("J Autism Dev Disord" 35:831-838, 2005) reported an association between "Dysbindin" and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in "Dysbindin." Our results suggest that genetic variation in "Dysbindin" may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between "Dysbindin" and PMA.
Descriptors: Schizophrenia, Patients, Genetics, Foreign Countries, Correlation, Adults, Adjustment (to Environment), Symptoms (Individual Disorders)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Germany