This paper presents a lifespan perspective of sexuality issues for individuals with developmental disabilities. Individuals with developmental disabilities are human beings who have historically been denied the right to express their sexuality or engage in sexual relationships due to misconceptions or negative attitudes. Using a hypothetical case to illustrate the challenges experienced by individuals with disabilities, human rights violations and the need for education and appropriate sexual information are highlighted. Issues such as eugenics, vulnerability to abuse, self-esteem, and individual differences are also discussed. Recommendations for practice are provided.