NotesFAQContact Us
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ814861
Record Type: Journal
Publication Date: 2008-Nov
Pages: 4
Abstractor: As Provided
Reference Count: 7
ISSN: ISSN-0021-9584
Experimental Design and Optimization: Application to a Grignard Reaction
Bouzidi, Naoual; Gozzi, Christel
Journal of Chemical Education, v85 n11 p1544-1547 Nov 2008
This project is conducted by students during the second semester of their second year in our educational institution. This project constitutes an initiation into research and allows a broadening of knowledge, a development in autonomy, organization, team work, and initiative. It helps prepare the student-engineer for an internship in industry. The experiment is done in student pairs over 5 weeks (three, eight-hour days per week). We introduce experimental design to undergraduate students because such methodology is increasingly important in modern industrial research. The well-prepared chemist will need to apply these concepts easily. Other pedagogical goals include increasing experience in synthetic techniques, scientific rigor to obtain reproducibility in the yield, and using quantitative analysis methods. This project investigates optimizing the synthesis of benzyl-1-cyclopentan-1-ol using experimental design. It is carried out in three steps: first the factors that can have a potential influence on the reaction are screened; second, a factorial design is used to study the interactions between the factors; and finally, response surface methodology is used to optimize the yield. (Contains 5 tables, 3 figures and 2 notes.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: France