Vitiligo is a chronic skin disease, which through change of appearance and body image, exerts a devastating effect on people, especially women. The objective of this study is to explore lived experience of women with Vitiligo by the hermeneutic phenomenology method. The purposive sample consisted of 16 Iranian women. Data analysis followed Diekelmann, Allen, and Tanner (1989). The results showed four main themes: (1) Perceiving myself in a different light; (2) Vitiligo: Worry about others' perceptions; (3) Vitiligo, Being influenced by cultural beliefs; and (4) Accepting and fighting the disease; Variations in experiences of living with Vitiligo. The women affected with Vitiligo during their marriage-ready years face various psychosocial problems such as rejection by associates, isolation, divorce, and forced choice of a single life. (Contains 1 footnote.)