ERIC Number: EJ799985
Record Type: Journal
Publication Date: 2008
Abstractor: As Provided
Reference Count: 0
The Human Lexinome: Genes of Language and Reading
Gibson, Christopher J.; Gruen, Jeffrey R.
Journal of Communication Disorders, v41 n5 p409-420 Sep-Oct 2008
Within the human genome, genetic mapping studies have identified 10 regions of different chromosomes, known as DYX loci, in genetic linkage with dyslexia, and two, known as SLI loci, in genetic linkage with Specific Language Impairment (SLI). Further genetic studies have identified four dyslexia genes within the DYX loci: "DYX1C1" on 15q, "KIAA0319" and "DCDC2" on 6p22, and "ROBO1" on 13q. "FOXP2" on 7q has been implicated in the development of Speech-Language Disorder. No genes for Specific Language Impairment have yet been identified within the two SLI loci. Functional studies have shown that all four dyslexia genes play roles in brain development, and ongoing molecular studies are attempting to elucidate how these genes exert their effects at a subcellular level. Taken together, these genes and loci likely represent only a fraction of the human lexinome, a term we introduce here to refer to the collection of all the genetic and protein elements involved in the development of human language, expression, and reading. Learning outcomes: The reader will become familiar with (i) methods for identifying genes for complex diseases, (ii) the application of these methods in the elucidation of genes underlying disorders of language and reading, and (iii) the cellular pathways through which polymorphisms in these genes may contribute to the development of the disorders.
Descriptors: Dyslexia, Genetics, Brain, Disabilities, Genetic Disorders, Language Impairments, Reading
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A