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ERIC Number: EJ788519
Record Type: Journal
Publication Date: 2008
Pages: 10
Abstractor: Author
Reference Count: 12
ISSN: ISSN-1043-4046
Teaching Calcium-Induced Calcium Release in Cardiomyocytes Using a Classic Paper by Fabiato
Liang, Willmann
Advances in Physiology Education, v32 n1 p1-10 2008
This teaching paper utilizes the materials presented by Dr. Fabiato in his review article entitled "Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum." In the review, supporting evidence of calcium-induced calcium release (CICR) is presented. Data concerning potential objections to the CICR theory are discussed as well. In closing, technical issues associated with the skinned cell model are mentioned. Based on this review article, teaching and learning points are put forth in this article to highlight two concepts: (1) the regulatory mechanisms of CICR in cardiomyocytes and (2) the recognition of contradicting hypotheses and limitations in experimental design. The first concept is certainly an important one for physiology students. The second concept is universally applicable to researchers in all fields of science. It is thus the aim of this article to cultivate a rewarding teaching and learning experience for both instructors and students. (Contains 2 tables and 6 figures.)
American Physiological Society. 9650 Rockville Pike, Bethesda, MD 20814-3991. Tel: 301-634-7164; Fax: 301-634-7241; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A