ERIC Number: EJ787705
Record Type: Journal
Publication Date: 2008-Mar
Reference Count: 0
Blockade of IP[subscript 3]-Mediated SK Channel Signaling in the Rat Medial Prefrontal Cortex Improves Spatial Working Memory
Brennan, Avis R.; Dolinsky, Beth; Vu, Mai-Anh T.; Stanley, Marion; Yeckel, Mark F.; Arnsten, Amy F. T.
Learning & Memory, v15 n3 p93-96 Mar 2008
Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP[subscript 3]-PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that IP[subscript 3] receptor (IP[subscript 3]R)-evoked calcium release results in SK channel-dependent hyperpolarization of prefrontal neurons. However, the effects of IP[subscript 3]R signaling on prefrontal function have not been investigated. The present findings demonstrate that blockade of IP[subscript 3]R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function.
Descriptors: Memory, Brain, Animals, Brain Hemisphere Functions, Short Term Memory, Cognitive Processes, Stress Variables
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A