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ERIC Number: EJ787704
Record Type: Journal
Publication Date: 2008-Mar
Pages: 6
Abstractor: Author
Reference Count: 0
ISBN: N/A
ISSN: ISSN-1072-0502
GABA[subscript A] Receptors Determine the Temporal Dynamics of Memory Retention
McNally, Gavan P.; Augustyn, Katarzyna A.; Richardson, Rick
Learning & Memory, v15 n3 p106-111 Mar 2008
Four experiments studied the role of GABA[subscript A] receptors in the temporal dynamics of memory retention. Memory for an active avoidance response was a nonmonotonic function of the retention interval. When rats were tested shortly (2 min) or some time (24 h) after training, retention was excellent, but when they were tested at intermediate intervals (1-4 h), retention was poor. Activity at GABA[subscript A] receptors was critical for impairing memory retention at the intermediate intervals because injection of the GABA[subscript A] receptor partial inverse agonist FG7142 prior to test significantly improved performance. These retention enhancing effects of FG7142 were dose-dependent and not due to any nonspecific effects of FG7142 on activity. Our results suggest that the temporal dynamics of memory retention may be caused by variations in neurotransmission through the GABA[subscript A] receptor in the post-training period.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Blvd, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A